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An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.
Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Fujita, Kazuhiro; Ushiki, Junko; Kuwabara, Takashi; Yamamoto, Yorihiro; Imamura, Toru.
Afiliação
  • Hosogi J; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan.
  • Ohashi R; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan.
  • Maeda H; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan.
  • Fujita K; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan.
  • Ushiki J; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan.
  • Kuwabara T; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan.
  • Yamamoto Y; School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakura-cho, Hachioji, Tokyo, 192-0983, Japan.
  • Imamura T; School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakura-cho, Hachioji, Tokyo, 192-0983, Japan.
Biopharm Drug Dispos ; 39(3): 164-174, 2018 Mar.
Article em En | MEDLINE | ID: mdl-29451686
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Piperazinas / Proteínas / Aldeído Oxidase / Indazóis Limite: Animals / Humans Idioma: En Revista: Biopharm Drug Dispos Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Piperazinas / Proteínas / Aldeído Oxidase / Indazóis Limite: Animals / Humans Idioma: En Revista: Biopharm Drug Dispos Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão