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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Seiler, Michael; Yoshimi, Akihide; Darman, Rachel; Chan, Betty; Keaney, Gregg; Thomas, Michael; Agrawal, Anant A; Caleb, Benjamin; Csibi, Alfredo; Sean, Eckley; Fekkes, Peter; Karr, Craig; Klimek, Virginia; Lai, George; Lee, Linda; Kumar, Pavan; Lee, Stanley Chun-Wei; Liu, Xiang; Mackenzie, Crystal; Meeske, Carol; Mizui, Yoshiharu; Padron, Eric; Park, Eunice; Pazolli, Ermira; Peng, Shouyong; Prajapati, Sudeep; Taylor, Justin; Teng, Teng; Wang, John; Warmuth, Markus; Yao, Huilan; Yu, Lihua; Zhu, Ping; Abdel-Wahab, Omar; Smith, Peter G; Buonamici, Silvia.
Afiliação
  • Seiler M; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Yoshimi A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Darman R; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Chan B; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Keaney G; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Thomas M; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Agrawal AA; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Caleb B; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Csibi A; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Sean E; Eisai Inc., Andover, Massachusetts, USA.
  • Fekkes P; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Karr C; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Klimek V; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Lai G; Eisai Inc., Andover, Massachusetts, USA.
  • Lee L; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Kumar P; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Lee SC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Liu X; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Mackenzie C; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Meeske C; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Mizui Y; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Padron E; Department of Hematologic Malignancies and Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
  • Park E; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Pazolli E; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Peng S; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Prajapati S; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Taylor J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Teng T; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Wang J; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Warmuth M; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Yao H; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Yu L; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Zhu P; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
  • Abdel-Wahab O; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Smith PG; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Buonamici S; H3 Biomedicine Inc., Cambridge, Massachusetts, USA.
Nat Med ; 24(4): 497-504, 2018 05.
Article em En | MEDLINE | ID: mdl-29457796
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Splicing de RNA / Spliceossomos / Bibliotecas de Moléculas Pequenas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Splicing de RNA / Spliceossomos / Bibliotecas de Moléculas Pequenas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos