Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma.

Qu, Chenxi; Li, Jizhao; Zhou, Yejuan; Yang, Shudi; Chen, Weiliang; Li, Fang; You, Bengang; Liu, Yang; Zhang, Xuenong

Qu, Chenxi; Li, Jizhao; Zhou, Yejuan; Yang, Shudi; Chen, Weiliang; Li, Fang; You, Bengang; Liu, Yang; Zhang, Xuenong.

Afiliação

Qu C; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
Li J; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
Zhou Y; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
Yang S; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
Chen W; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
Li F; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
You B; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
Liu Y; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China.
Zhang X; Department of Pharmaceutics, College of Pharmaceutical Sciences, DuShuHu High Education Zone, Soochow University, Suzhou, 215123, Jiang Su Province, People's Republic of China. zhangxuenong@163.com.

AAPS J ; 20(2): 34, 2018 02 23.

Article em En | MEDLINE | ID: mdl-29476273

Assuntos

Antibióticos Antineoplásicos/administração & dosagem; Carcinoma Hepatocelular/tratamento farmacológico; Doxorrubicina/administração & dosagem; Sistemas de Liberação de Medicamentos/métodos; Neoplasias Hepáticas/tratamento farmacológico; Animais; Anticorpos Monoclonais/imunologia; Anticorpos Monoclonais/metabolismo; Basigina/imunologia; Linhagem Celular Tumoral; Preparações de Ação Retardada/administração & dosagem; Feminino; Humanos; Concentração de Íons de Hidrogênio; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Micelas; Nanopartículas/química; Nanopartículas/metabolismo; Ratos; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

CD147; ROS/pH dual sensitivity; doxorubicin; micelles

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Doxorrubicina / Sistemas de Liberação de Medicamentos / Carcinoma Hepatocelular / Neoplasias Hepáticas / Antibióticos Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: AAPS J Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2018 Tipo de documento: Article

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