Phosphorylated Hsp27 is mutually exclusive with ATRX loss and the IDH1<sup>R132H</sup> mutation and may predict better prognosis among glioblastomas without the IDH1 mutation and ATRX loss.

Cai, Hong-Qing; Wang, Peng-Fei; Zhang, Hai-Peng; Cheng, Zhi-Jian; Li, Shou-Wei; He, Jie; Zhang, Yu; Hao, Jia-Jie; Wang, Ming-Rong; Yan, Chang-Xiang; Wan, Jing-Hai

Phosphorylated Hsp27 is mutually exclusive with ATRX loss and the IDH1^R132H mutation and may predict better prognosis among glioblastomas without the IDH1 mutation and ATRX loss.

Cai, Hong-Qing; Wang, Peng-Fei; Zhang, Hai-Peng; Cheng, Zhi-Jian; Li, Shou-Wei; He, Jie; Zhang, Yu; Hao, Jia-Jie; Wang, Ming-Rong; Yan, Chang-Xiang; Wan, Jing-Hai.

Afiliação

Cai HQ; Department of Neurosurgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang PF; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang HP; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Cheng ZJ; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Li SW; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
He J; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Zhang Y; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Hao JJ; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang MR; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yan CX; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wan JH; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

J Clin Pathol ; 71(8): 702-707, 2018 Aug.

Article em En | MEDLINE | ID: mdl-29550762

Assuntos

Biomarcadores Tumorais/análise; Neoplasias Encefálicas/enzimologia; Glioblastoma/enzimologia; Proteínas de Choque Térmico HSP27/análise; Isocitrato Desidrogenase/análise; Proteína Nuclear Ligada ao X/análise; Adolescente; Adulto; Idoso; Biomarcadores Tumorais/genética; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/mortalidade; Neoplasias Encefálicas/patologia; Distribuição de Qui-Quadrado; Feminino; Glioblastoma/genética; Glioblastoma/mortalidade; Glioblastoma/patologia; Proteínas de Choque Térmico; Humanos; Imuno-Histoquímica; Isocitrato Desidrogenase/genética; Estimativa de Kaplan-Meier; Masculino; Pessoa de Meia-Idade; Chaperonas Moleculares; Mutação; Gradação de Tumores; Fosforilação; Fatores de Tempo; Análise Serial de Tecidos; Adulto Jovem

Palavras-chave

ATRX; Hsp27; IDH1; glioma; prognosis

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Biomarcadores Tumorais / Glioblastoma / Proteínas de Choque Térmico HSP27 / Proteína Nuclear Ligada ao X / Isocitrato Desidrogenase Tipo de estudo: Guideline / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Pathol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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