Prevalence and age-wise distribution of Human Papillomavirus type 16/18 infections among hospital screened women of a peri-urban area in West Bengal: Impact of socio-demographic factors.
Cancer Epidemiol
; 54: 31-37, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29571035
ABSTRACT
BACKGROUND:
We undertook the current study on cervical Human Papillomavirus (HPV) prevalence along with cytology in women visiting the Gynecology Out-patient Department of a hospital for common gynecological ailments, subsequent to our earlier population-based study on HPV prevalence from India.METHODS:
We analyzed data on cervical-cytology (Pap smears) and PCR-based molecular detection of HPV infection along with socio-demographic variables (Nâ¯=â¯696).RESULTS:
We identified 36.84% HPV-positive women amongst whom, HPV16 and 18 together predominated (79.37%) over other HPV types (20.63%). Contrarily, only 6.4% women revealed abnormal cytological lesions, of which, 46.51% were HPV-positive and 95% of such women harbored HPV16/18, while 5% harbored other HPV types. Individuals with normal cytology portrayed 36.09% HPV infections, of which, 77.97% were HPV16/18-positive and 22.03% harbored other HPV types. Overall HPV prevalence decreased significantly (ptrend â¯=â¯0.047) with increase in age, but HPV16/18 infections were significantly over-represented compared to the other HPV types across all age-groups. Specifically, HPV16 prevalence increased (p trendâ¯<â¯0.01) with increase in severity of cervical lesions. HPV16 prevalence did not differ between the Hindus and Muslims but HPV18 was significantly higher among the cytologically normal Muslim women (24.14%, pâ¯=â¯0.02), compared to the Hindus (11.91%), specifically among those ≥â¯30 years of age. There was a significant (pâ¯<â¯0.05) overrepresentation of HPV16 prevalence among women who were users of oral contraceptive-pills, irrespective of cytology.CONCLUSIONS:
Our study highlights the need for HPV16/18-based screening of cervical cancers in India considering the immense socio-cultural and genetic diversity at the population level.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Incidencia
/
Geral
/
Prevencao_e_fatores_de_risco
/
Atos_sexuais
/
Saude_da_mulher
/
Colo_do_utero
/
Colo_do_utero
Base de dados:
MEDLINE
Assunto principal:
Programas de Rastreamento
/
Infecções por Papillomavirus
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Papillomavirus Humano 16
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Papillomavirus Humano 18
Tipo de estudo:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
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Female
/
Humans
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Cancer Epidemiol
Assunto da revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Ano de publicação:
2018
Tipo de documento:
Article