Influence of the Vitreoretinal Interface on the Treatment with Anti-VEGF for Exudative Age-Related Macular Degeneration.
Ophthalmologica
; 240(1): 29-36, 2018.
Article
em En
| MEDLINE
| ID: mdl-29734180
ABSTRACT
PURPOSE:
To investigate the influence of the vitreoretinal interface on the outcomes of different ranibizumab regimens for exudative age-related macular degeneration.METHODS:
We conducted a retrospective subanalysis of 2 prospective clinical trials. Patients were treated with ranibizumab for 12 months according to 3 different regimens pro-re-nata (PRN), treat and extend (T&E), and monthly. Vitreoretinal interface was assessed for absence (group ON) or presence (group OFF) of posterior vitreous detachment (PVD).RESULTS:
We included 64 eyes from 64 patients. Visual improvement was poorer for group ON (0.3 ± 10.7 letters) than for group OFF (9.2 ± 13.3; p = 0.007). A significant difference in letters of improvement between groups was observed in the PRN cohort (ON -5.0 ± 12.9; OFF 11.4 ± 11.9; p = 0.003), but not in the cohorts with monthly (ON 5.7 ± 7.8; OFF 7.9 ± 15.2; p = 0.735) or T&E (ON 4.3 ± 4.3; OFF 7.8 ± 11.1; p = 0.424) treatment.CONCLUSION:
The negative impact of absence of PVD is regimen dependent, with monthly dosing providing similar outcomes to PVD patients. In the absence of PVD (group ON), PRN should be avoided, and T&E might be an alternative.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Corpo Vítreo
/
Descolamento do Vítreo
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Inibidores da Angiogênese
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Degeneração Macular Exsudativa
/
Ranibizumab
Tipo de estudo:
Observational_studies
Limite:
Aged
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Female
/
Humans
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Male
Idioma:
En
Revista:
Ophthalmologica
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Portugal