Novel Neuroprotective Lead Compound Ligustrazine Derivative Mass Spectrometry Fragmentation Rule and Metabolites in Rats by LC/LTQ-Orbitrap MS.

Zhang, Xinyu; Zhao, Rui; Chen, Meng; Ma, Tao; Wu, Gaorong; Xue, Nannan; Li, Guoliang; Wang, Hui; Fang, Kang; Zhang, Wenxi; Wang, Penglong; Lei, Haimin

Zhang, Xinyu; Zhao, Rui; Chen, Meng; Ma, Tao; Wu, Gaorong; Xue, Nannan; Li, Guoliang; Wang, Hui; Fang, Kang; Zhang, Wenxi; Wang, Penglong; Lei, Haimin.

Afiliação

Zhang X; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 20160931837@bucm.edu.cn.
Zhao R; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. zr1012zr@126.com.
Chen M; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. chenmeng_0809@163.com.
Ma T; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. mosesmatao@163.com.
Wu G; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. gaorongwu09@163.com.
Xue N; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18810612758@163.com.
Li G; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. liguoliangsx@163.com.
Wang H; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 15652387323@163.com.
Fang K; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18364166994@163.com.
Zhang W; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. zhangwxnn@126.com.
Wang P; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. wpl581@126.com.
Lei H; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. hm_lei@126.com.

Molecules ; 23(5)2018 05 11.

Article em En | MEDLINE | ID: mdl-29751639

Assuntos

Cromatografia Líquida; Fármacos Neuroprotetores/química; Fármacos Neuroprotetores/farmacocinética; Pirazinas/química; Pirazinas/farmacocinética; Espectrometria de Massas em Tandem; Animais; Sobrevivência Celular/efeitos dos fármacos; Cromatografia Líquida/métodos; Masculino; Redes e Vias Metabólicas; Metabolômica/métodos; Fármacos Neuroprotetores/metabolismo; Células PC12; Pirazinas/metabolismo; Ratos; Espectrometria de Massas em Tandem/métodos

Palavras-chave

fragmentation regularities; ligustrazine derivative metabolites; liquid chromatography-electrospray ionizationion trap mass spectrometry (LC/LTQ-Orbitrap MS); neuroprotective activity

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Pirazinas / Cromatografia Líquida / Fármacos Neuroprotetores / Espectrometria de Massas em Tandem Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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