Association of interleukin-6 (rs1800796) but not transforming growth factor beta 1 (rs1800469) with serum calcium levels in osteoporotic patients.
Gene
; 671: 21-27, 2018 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-29860063
ABSTRACT
BACKGROUND:
Osteoporosis is a multifactorial disease with a strong genetic influence. Recent studies have demonstrated that cytokines, such as TGF-ß1 and interleukin 6 (IL-6) play complex roles in the normal bone metabolism and pathophysiology of osteoporosis. Here, we investigated the roles of 2 polymorphisms mapping to the promoters of TGF-ß1and IL-6 genes on the genetic susceptibility to osteoporosis as well as calcium and vitamin D levels.METHODS:
A cohort of 297 elderly participants in northern Iran comprising 181 osteoporotic patients (mean age⯱â¯SD, 68.36⯱â¯7.21â¯years) and 116 unrelated healthy controls (mean age⯱â¯SD, 64⯱â¯5.44â¯years) was studied for TGF-ß1(C-509T) and IL-6 (G-634C) polymorphisms using PCR-RFLP method.RESULTS:
A significant relationship was observed between calcium level and IL-6 genotypes in osteoporotic males (Pâ¯=â¯0.011) and females (Pâ¯=â¯0.020). No significant differences were observed between osteoporotic and control groups with respect to allele frequency or genotype distribution based on the 2 selected polymorphisms under different genetic models. The results remained the same after comparing the BMD values of either the femur neck or lumbar spine with the genotypes of the elderly men and women when analyzed separately.CONCLUSION:
IL-6 genotype influences serum calcium levels in osteoporotic patients. The lack of association between the common genetic variations of TGF-ß1 and IL-6 genes, and BMD highlights the complex genetic background of osteoporosis in the north of Iran.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Cálcio
/
Interleucina-6
/
Polimorfismo de Nucleotídeo Único
/
Fator de Crescimento Transformador beta1
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Gene
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Irã