Sensitive and selective gas chromatography-tandem mass spectrometry method for the detection of nitrobenzene in tobacco smoke.
J Chromatogr A
; 1565: 124-129, 2018 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-29945789
ABSTRACT
Nitrobenzene, a potentially harmful compound found in tobacco smoke, has been largely excluded from prior analysis due to difficulties with quantification. Quantifying harmful compounds in cigarette smoke is useful to compare products, to examine the impact of design parameters on delivery, and to help estimate exposures. A sensitive high-throughput method has been developed for quantifying nitrobenzene in machine-generated mainstream cigarette smoke using isotope dilution gas chromatography-tandem mass spectrometry (ID-GC-MS/MS). This method has sufficient sensitivity to measure vapor phase nitrobenzene concentrations in the low nanogram range, with a 418â¯pg/cig method limit of detection. Precision estimates from two quality control cigarette products resulted in percent relative standard deviations of 11.5% and 14.9%; product variability estimates from 13 cigarette products resulted in percent relative standard deviations ranging from 2.8% to 16.9%. Nitrobenzene in the machine-generated, mainstream smoke from 15 cigarette products are reported and range from 18 to 38â¯ng/cig under the Health Canada Intense smoking regimen.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Agentes_cancerigenos
Base de dados:
MEDLINE
Assunto principal:
Nicotiana
/
Poluição por Fumaça de Tabaco
/
Cromatografia Gasosa-Espectrometria de Massas
/
Nitrobenzenos
Tipo de estudo:
Diagnostic_studies
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Chromatogr A
Ano de publicação:
2018
Tipo de documento:
Article