Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way.
Cell Prolif
; 51(5): e12467, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-29947118
ABSTRACT
Apoptosis is a mode of regulated cell death that is indispensable for the morphogenesis, development and homeostasis of multicellular organisms. Caspases are cysteine-dependent aspartate-specific proteases, which function as initiators and executors of apoptosis. Caspases are cytosolic proteins that can cleave substrates located in different intracellular compartments during apoptosis. Many years ago, the involvement of caspases in the regulation of nuclear changes, a hallmark of apoptosis, was documented. Accumulated data suggest that apoptosis-associated alterations in nucleocytoplasmic transport are also linked to caspase activity. Here, we aim to discuss the current state of knowledge regarding this process. Particular attention will be focused on caspase nuclear entry and their functions in the demolition of the nucleus upon apoptotic stimuli.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Apoptose
/
Caspases
/
Transporte Ativo do Núcleo Celular
/
Citoplasma
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Prolif
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Federação Russa