Pd-Catalyzed Direct C-H Functionalization/Annulation of BODIPYs with Alkynes to Access Unsymmetrical Benzo[ b]-Fused BODIPYs: Discovery of Lysosome-Targeted Turn-On Fluorescent Probes.
J Org Chem
; 83(16): 9538-9546, 2018 08 17.
Article
em En
| MEDLINE
| ID: mdl-29979039
ABSTRACT
A highly efficient palladium-catalyzed direct C-H functionalization/annulation of BODIPYs with alkynes has been developed for the first time to construct a series of unsymmetrical benzo[ b]-fused BODIPYs from readily available starting materials. These unsymmetrical benzo[ b]-fused BODIPYs exhibit remarkably red-shifted emissions and larger Stokes shifts than classical BODIPY dyes. Cell imaging experiments and cytotoxicity assays demonstrate that BODIPYs 4c and 4d have specific lysosome-labeling capacities, turn-on fluorescence emissions in cells, and low cytotoxicity.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Compostos de Boro
/
Carbono
/
Alcinos
/
Hidrogênio
/
Lisossomos
Limite:
Humans
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2018
Tipo de documento:
Article