Nanoparticle uptake by circulating leukocytes: A major barrier to tumor delivery.

Betker, Jamie L; Jones, Dallas; Childs, Christine R; Helm, Karen M; Terrell, Kristina; Nagel, Maria A; Anchordoquy, Thomas J

Betker, Jamie L; Jones, Dallas; Childs, Christine R; Helm, Karen M; Terrell, Kristina; Nagel, Maria A; Anchordoquy, Thomas J.

Afiliação

Betker JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Jones D; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Childs CR; Flow Cytometry Core Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Helm KM; Flow Cytometry Core Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Terrell K; Flow Cytometry Core Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Nagel MA; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Anchordoquy TJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. Electronic address: tom.anchordoquy@ucdenver.edu.

J Control Release ; 286: 85-93, 2018 09 28.

Article em En | MEDLINE | ID: mdl-30030182

Assuntos

Leucócitos/metabolismo; Nanopartículas/metabolismo; Polietilenoglicóis/metabolismo; Animais; DNA/administração & dosagem; DNA/farmacocinética; Feminino; Técnicas de Transferência de Genes; Camundongos Endogâmicos BALB C; Camundongos SCID; Neoplasias/metabolismo; Plasmídeos/administração & dosagem; Plasmídeos/farmacocinética; Distribuição Tecidual

Palavras-chave

Gene delivery; Leukocyte uptake; Lipoplexes; PEGylation

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Nanopartículas / Leucócitos Limite: Animals Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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