Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort.
Mult Scler
; 25(12): 1572-1579, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-30124094
ABSTRACT
BACKGROUND AND OBJECTIVE:
Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.METHODS:
A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.RESULTS:
We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women (p < 0.001) and men (p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI) 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI 0.38-0.62) and high consumption (OR = 0.57, 95% CI 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.CONCLUSION:
Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
/
Fumar
/
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Mult Scler
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Dinamarca