Three New Monoterpenoid Indole Alkaloids from Ervatamia pandacaqui.

Zhang, Jian; Ao, Yun-Lin; Yao, Nan; Bai, Wen-Xin; Fan, Chun-Lin; Ye, Wen-Cai; Zhang, Xiao-Qi

Zhang, Jian; Ao, Yun-Lin; Yao, Nan; Bai, Wen-Xin; Fan, Chun-Lin; Ye, Wen-Cai; Zhang, Xiao-Qi.

Afiliação

Zhang J; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Ao YL; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Yao N; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Bai WX; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Fan CL; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Ye WC; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Zhang XQ; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.

Chem Biodivers ; 15(10): e1800268, 2018 Oct.

Article em En | MEDLINE | ID: mdl-30133137

RESUMO

Three new monoterpenoid indole alkaloids, ervapandine A (1), (3R)-hydroxyibogaine (3), 12-hydroxyakuammicine N(4)-oxide (6), along with four known ones, were isolated from the twigs and leaves of Ervatamia pandacaqui. The structures of the new alkaloids were elucidated by spectroscopic methods and sugar hydrolysis experiment. All of the compounds were evaluated for their cytotoxicity against three human cell lines. Compound 7 showed moderate cytotoxic activity.

Assuntos

Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/farmacologia; Apocynaceae/química; Alcaloides de Triptamina e Secologanina/química; Alcaloides de Triptamina e Secologanina/farmacologia; Antineoplásicos Fitogênicos/isolamento & purificação; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Modelos Moleculares; Neoplasias/tratamento farmacológico; Alcaloides de Triptamina e Secologanina/isolamento & purificação

Palavras-chave

Ervatamia pandacaqui; Apocynaceae; cytotoxic activities; monoterpenoid indole alkaloids

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Apocynaceae / Alcaloides de Triptamina e Secologanina / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article

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