Automated SPE-based synthesis of 16α-[18F]fluoroestradiol without HPLC purification step.
Appl Radiat Isot
; 141: 57-63, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-30176563
ABSTRACT
[18F]fluoroestradiol ([18F]FES) is well-established PET radiotracer for diagnosing and monitoring treatment of estrogen-positive breast cancer. The radiotracer is produced via one-pot two steps synthesis using cyclic sulfate precursor and is usually purified by semi-preparative HPLC. Here we suggested simple SPE purification procedure using OASIS WAX 3cc and Sep-Pak QMA light cartridges that afforded [18F]FES in typically 15% RCY (corrected for decay) within 45â¯min formulated in 5% EtOH/saline. All purity parameters were well within specifications recommended in the Investigator's Brochure for [18F]Fluoroestradiol.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Radioisótopos de Flúor
/
Compostos Radiofarmacêuticos
/
Estradiol
/
Extração em Fase Sólida
Limite:
Female
/
Humans
Idioma:
En
Revista:
Appl Radiat Isot
Assunto da revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Federação Russa