Exposure to aluminum, aluminumâ¯+â¯manganese and acid pH triggers different antioxidant responses in gills and liver of Astyanax altiparanae (Teleostei: Characiformes: Characidae) males.
Comp Biochem Physiol C Toxicol Pharmacol
; 215: 33-40, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30315923
ABSTRACT
Exposure to aluminum (Al) and aluminumâ¯+â¯manganese (Mn) can trigger an increase in reactive oxygen species (ROS) and modify the activity of oxidative defense enzymes. This study investigated whether exposure to Al and Alâ¯+â¯Mn at acid pH for 24 and 96â¯h causes oxidative stress evidenced by antioxidants and oxidative damage in the gills and liver of sexually mature Astyanax altiparanae males. The fish were subsequently immersed in metal-free water for 24 and 96â¯h to see whether they recovered from the effects of these metals. Exposure to an acid pH boosted the activity of gill superoxide dismutase (SOD) at 96â¯h and the fish did not recover when immersed for the same period in water at neutral pH. Exposure to Al increased glutathione (GSH) levels (24â¯h) in the gills, returning to control levels during the recovery period, showing the efficiency of the antioxidant system in preventing lipid peroxidation of the gills and liver. Mn did not modify the activity of the enzymes studied, but did trigger late hepatic lipid peroxidation during the recovery period. The group exposed to Alâ¯+â¯Mn exhibited several alterations, including increased concentration of GSH, as well as higher GPx and GR activity in the gills. Despite the defensive responses triggered by acute exposure, during the recovery period there were alterations in catalase (96â¯h) and an increase in hepatic metallothionein (24â¯h), but this did not prevent hepatic lipid peroxidation. Al and Alâ¯+â¯Mn produced different effects, and the timing of enzymatic and non-enzymatic antioxidant defenses also differed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Agentes_cancerigenos
Base de dados:
MEDLINE
Assunto principal:
Poluição Química da Água
/
Estresse Oxidativo
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Alumínio
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Characidae
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Brânquias
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Fígado
/
Manganês
Limite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Toxicol Pharmacol
Assunto da revista:
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil