Suppression of free fatty acid receptor 1 expression in pancreatic ß-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1.

Kohara, Kenji; Obata, Atsushi; Kimura, Tomohiko; Shimoda, Masashi; Moriuchi, Saeko; Okauchi, Seizo; Hirukawa, Hidenori; Mune, Tomoatsu; Kaku, Kohei; Kaneto, Hideaki

Kohara, Kenji; Obata, Atsushi; Kimura, Tomohiko; Shimoda, Masashi; Moriuchi, Saeko; Okauchi, Seizo; Hirukawa, Hidenori; Mune, Tomoatsu; Kaku, Kohei; Kaneto, Hideaki.

Afiliação

Kohara K; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Obata A; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Kimura T; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Shimoda M; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Moriuchi S; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Okauchi S; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Hirukawa H; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Mune T; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Kaku K; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Kaneto H; Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

Endocr J ; 66(1): 43-50, 2019 Jan 28.

Article em En | MEDLINE | ID: mdl-30333365

Assuntos

Diabetes Mellitus Tipo 2/genética; Proteínas de Homeodomínio/genética; Secreção de Insulina; Células Secretoras de Insulina/metabolismo; Obesidade/genética; RNA Mensageiro/metabolismo; Receptores Acoplados a Proteínas G/genética; Transativadores/genética; Animais; Linhagem Celular; Diabetes Mellitus Tipo 2/metabolismo; Modelos Animais de Doenças; Proteínas de Homeodomínio/metabolismo; Masculino; Camundongos; Obesidade/metabolismo; RNA Interferente Pequeno; Receptores Acoplados a Proteínas G/metabolismo; Transativadores/metabolismo

Palavras-chave

Free fatty acid receptor 1/G protein-coupled receptor 40 (GPR40); Pancreatic and duodenal homeobox factor 1; Pancreatic ß-cells; Type 2 diabetes mellitus; ß-cell glucose insensitivity

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Transativadores / Proteínas de Homeodomínio / Receptores Acoplados a Proteínas G / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Secreção de Insulina / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Endocr J Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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