[FIBROBLAST ACTIVATION PROTEIN (FAP) AS A POSSIBLE TARGET OF THE ANTITUMOR STRATEGY.]
Mol Gen Mikrobiol Virusol
; 34(3): 90-97, 2016.
Article
em Ru
| MEDLINE
| ID: mdl-30383930
ABSTRACT
This review was devoted to the use of the versatile component oftumoral stroma (fibroblast activation protein, FAP) as a target of the versatile tumor therapy. The tumor is a coevolution system, which includes the microenvironment or reactive stroma differing from the normal tissue by the phenotypic and genotypic features. Important elements of the tumor microenvironment are cancer-associated fibroblasts (CAFs), which contain typical marker FAP (serine proteinase with the enzymatic activity of dipeptidyl peptidase and endopeptidase). According to the literature, more than 90% of tumors contain FAP-positive activated fibroblasts. FAP is virtually absent in normal tissues, but it is present in the embryonic and tumor tissues, which makes it a selective and versatile model. In this work, basic approaches to affecting the CAF using FAP as a target were discussed. The use of FAP as a target provides an important advantage its proteolytic activity can be used along with the protein-targeted agents. The main directions in the therapeutic use of FAP were discussed in this work.
Buscar no Google
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Serina Endopeptidases
/
Biomarcadores Tumorais
/
Gelatinases
/
Microambiente Tumoral
/
Proteínas de Membrana
/
Proteínas de Neoplasias
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
Ru
Revista:
Mol Gen Mikrobiol Virusol
Assunto da revista:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
/
VIROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article