An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity.

Juarez, Eleonora; Chambwe, Nyasha; Tang, Weiliang; Mitchell, Asia D; Owen, Nichole; Kumari, Anuradha; Monnat, Raymond J; McCullough, Amanda K

Juarez, Eleonora; Chambwe, Nyasha; Tang, Weiliang; Mitchell, Asia D; Owen, Nichole; Kumari, Anuradha; Monnat, Raymond J; McCullough, Amanda K.

Afiliação

Juarez E; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, United States.
Chambwe N; Institute for Systems Biology, Seattle, WA 98109, United States.
Tang W; Departments of Pathology and Genome Sciences, University of Washington, Seattle, WA, 98195, United States.
Mitchell AD; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States.
Owen N; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, United States.
Kumari A; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, United States.
Monnat RJ; Departments of Pathology and Genome Sciences, University of Washington, Seattle, WA, 98195, United States.
McCullough AK; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, United States. Electronic address: mcculloa@ohsu.edu.

DNA Repair (Amst) ; 72: 1-9, 2018 12.

Article em En | MEDLINE | ID: mdl-30389308

Assuntos

Dano ao DNA; Reparo do DNA/efeitos dos fármacos; Reparo do DNA/genética; Formaldeído/toxicidade; Interferência de RNA; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Genômica; Humanos

Palavras-chave

DNA damage response; DNA repair; Double-strand break repair; Formaldehyde; siRNA screen

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Prevencao_e_fatores_de_risco / Agentes_cancerigenos Base de dados: MEDLINE Assunto principal: Dano ao DNA / Interferência de RNA / Reparo do DNA / Formaldeído Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: DNA Repair (Amst) Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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