Oxygen Starvation Unmasks a Killer.

Svec, Riley L; Hergenrother, Paul J

Svec, Riley L; Hergenrother, Paul J.

Afiliação

Svec RL; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Hergenrother PJ; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: hergenro@illinois.edu.

Cell Chem Biol ; 25(11): 1313-1314, 2018 11 15.

Article em En | MEDLINE | ID: mdl-30445051

ABSTRACT

ABSTRACT

In this issue of Cell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors.

Assuntos

Neoplasias; Oxigênio; Hipóxia Celular; Humanos; Hipóxia; Mitocôndrias

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Oxigênio / Neoplasias Limite: Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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