Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients.
Reprod Biomed Online
; 38(1): 13-21, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30446308
ABSTRACT
RESEARCH QUESTION Reports on the effect of adenomyosis on assisted reproductive technology (ART) outcomes are conflicting. Does presence of adenomyosis affect reproductive outcome in IVF cycles in women pretreated with gonadotrophin releasing hormone (GnRH) agonist? DESIGN:
In this retrospective cohort study, 973 women were divided into four groups only endometriosis (nâ¯=â¯355); endometriosis and adenomyosis (nâ¯=â¯88); adenomyosis alone (nâ¯=â¯64); and tubal factor infertility as controls (nâ¯=â¯466). The pregnancy outcome parameters (clinical pregnancy, miscarriage rate, live birth rate) were compared between these groups.RESULTS:
The clinical pregnancy rate was 36.62% in women with endometriosis alone, 22.72% in women with endometriosis and adenomyosis, 23.44% in women who only had adenomyosis and 34.55% in controls. Miscarriage rates were as follows 14.62%, 35%, 40% and 13.04%, respectively. Live birth rates were 27.47% in controls; 26.48% in women with only endometriosis; 11.36% in women with endometriosis and adenomyosis; and 12.5% in women with only adenomyosis. Live birth was observed to be less in adenomyosis groups compared with controls and women with only endometriosis. No significant difference was observed in clinical pregnancy, miscarriage or live birth rate between controls and women with only endometriosis. Live birth rate was significantly different between controls and women with adenomyosis only (Pâ¯=â¯0.01) and women with endometriosis and adenomyosis (Pâ¯=â¯0.002).CONCLUSION:
Presence of adenomyosis seems to have adverse effects on IVF outcomes in clinical pregnancy rate, live birth rate and miscarriage rate. Screening for adenomyosis might be considered before ART so that the couple has better awareness of the prognosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Fertilização in vitro
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Taxa de Gravidez
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Endometriose
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Adenomiose
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Infertilidade Feminina
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Reprod Biomed Online
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2019
Tipo de documento:
Article