Chitosan Oligosaccharides Improve Glucolipid Metabolism Disorder in Liver by Suppression of Obesity-Related Inflammation and Restoration of Peroxisome Proliferator-Activated Receptor Gamma (PPARÎ³).

Bai, Yibo; Zheng, Junping; Yuan, Xubing; Jiao, Siming; Feng, Cui; Du, Yuguang; Liu, Hongtao; Zheng, Lanyan

Bai, Yibo; Zheng, Junping; Yuan, Xubing; Jiao, Siming; Feng, Cui; Du, Yuguang; Liu, Hongtao; Zheng, Lanyan.

Afiliação

Bai Y; Department of Pathogen Biology, College of Basic Medical Sciences, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. YiboBaicmu@163.com.
Zheng J; State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. YiboBaicmu@163.com.
Yuan X; State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. junpingzheng2013@163.com.
Jiao S; Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, China. junpingzheng2013@163.com.
Feng C; State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. xbyuan@ipe.ac.cn.
Du Y; State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. smjiao@ipe.ac.cn.
Liu H; State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. cfeng@ipe.ac.cn.
Zheng L; State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. ygdu@ipe.ac.cn.

Mar Drugs ; 16(11)2018 Nov 19.

Article em En | MEDLINE | ID: mdl-30463189

Assuntos

Quitosana/farmacologia; Glicolipídeos/metabolismo; Síndrome Metabólica/tratamento farmacológico; Obesidade/tratamento farmacológico; Oligossacarídeos/farmacologia; Animais; Quitosana/química; Quitosana/uso terapêutico; Citocinas/imunologia; Citocinas/metabolismo; Dieta Hiperlipídica/efeitos adversos; Modelos Animais de Doenças; Células Hep G2; Humanos; Mediadores da Inflamação/imunologia; Mediadores da Inflamação/metabolismo; Metabolismo dos Lipídeos/efeitos dos fármacos; Fígado/efeitos dos fármacos; Fígado/metabolismo; Fígado/patologia; Masculino; Síndrome Metabólica/etiologia; Síndrome Metabólica/imunologia; Síndrome Metabólica/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Obesidade/etiologia; Obesidade/imunologia; Obesidade/metabolismo; Oligossacarídeos/química; Oligossacarídeos/uso terapêutico; PPAR gama/metabolismo; Resultado do Tratamento; Regulação para Cima

Palavras-chave

chitosan oligosaccharide; glucolipid metabolism disorder; high-fat diet; inflammation; peroxisome proliferator-activated receptor gamma

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Glicolipídeos / Síndrome Metabólica / Quitosana / Obesidade Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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