Diminazene aceturate (Berenil) downregulates Trypanosoma congolense-induced proinflammatory cytokine production by altering phosphorylation of MAPK and STAT proteins.

Kuriakose, Shiby M; Onyilagha, Chukwunonso; Singh, Rani; Jia, Ping; Uzonna, Jude E

Kuriakose, Shiby M; Onyilagha, Chukwunonso; Singh, Rani; Jia, Ping; Uzonna, Jude E.

Afiliação

Kuriakose SM; Parasite Vaccines Development Laboratory, Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Onyilagha C; Parasite Vaccines Development Laboratory, Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Singh R; Parasite Vaccines Development Laboratory, Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Jia P; Parasite Vaccines Development Laboratory, Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Uzonna JE; Parasite Vaccines Development Laboratory, Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada. jude.uzonna@umanitoba.ca.

Immunol Res ; 67(1): 84-92, 2019 02.

Article em En | MEDLINE | ID: mdl-30467677

Assuntos

Diminazena/análogos & derivados; Macrófagos/imunologia; Tripanossomicidas/uso terapêutico; Trypanosoma congolense/fisiologia; Tripanossomíase Africana/tratamento farmacológico; Animais; Bovinos; Linhagem Celular Transformada; Citocinas/metabolismo; Diminazena/uso terapêutico; Feminino; Humanos; Mediadores da Inflamação/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Fosforilação; Fator de Transcrição STAT1/metabolismo; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais; Tripanossomíase Africana/imunologia; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Diminazene aceturate (Berenil); MAPK; Macrophages; Proinflammatory cytokines; STAT1; Trypanosome

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Tripanossomíase Africana / Trypanosoma congolense / Diminazena / Macrófagos Limite: Animals / Female / Humans Idioma: En Revista: Immunol Res Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá

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