Paclitaxel-betulinic acid hybrid nanosuspensions for enhanced anti-breast cancer activity.

Wang, Ruoning; Yang, Mengmeng; Li, Guoyuan; Wang, Xin; Zhang, Zhenhai; Qiao, Hongzhi; Chen, Jun; Chen, Zhipeng; Cui, Xiaobin; Li, Junsong

Wang, Ruoning; Yang, Mengmeng; Li, Guoyuan; Wang, Xin; Zhang, Zhenhai; Qiao, Hongzhi; Chen, Jun; Chen, Zhipeng; Cui, Xiaobin; Li, Junsong.

Afiliação

Wang R; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China.
Yang M; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China.
Li G; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China.
Wang X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China.
Zhang Z; Jiangsu Provincial Academy of Chinese Medicine, Nanjing, 210028, China.
Qiao H; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China.
Chen J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China.
Chen Z; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China.
Cui X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Li J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing, 210023, China. Electronic address: lijunsong1964@163.com.

Colloids Surf B Biointerfaces ; 174: 270-279, 2019 Feb 01.

Article em En | MEDLINE | ID: mdl-30469048

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Neoplasias Mamárias Experimentais/tratamento farmacológico; Neoplasias Mamárias Experimentais/patologia; Nanopartículas/química; Paclitaxel/farmacologia; Triterpenos/farmacologia; Animais; Antineoplásicos Fitogênicos/química; Apoptose/efeitos dos fármacos; Neoplasias da Mama/patologia; Ciclo Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Humanos; Células MCF-7; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Paclitaxel/química; Triterpenos Pentacíclicos; Relação Estrutura-Atividade; Distribuição Tecidual; Triterpenos/química; Ácido Betulínico

Palavras-chave

Betulinic acid; Breast cancer; Nanosuspensions; Paclitaxel; Synergistic action

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Triterpenos / Neoplasias da Mama / Paclitaxel / Nanopartículas / Neoplasias Mamárias Experimentais / Antineoplásicos Fitogênicos Limite: Animals / Female / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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