Pancreatic Grafts from Pediatric Donors Do Not Appear to Grow After Transplantation into Adults.

ABSTRACT

Unlike pediatric kidney donors, there is no literature regarding the growth of pediatric donor pancreatic transplant grafts. Our center prospectively followed three pediatric donor grafts after transplant by measuring two dimensions of the graft at postoperative day one and then at one, two, and three months post-transplant surgery with the hypothesis that the grafted pancreas would not grow like pediatric kidney donors given the fundamental physiologic differences between these two organs. Two grafts were stable to minimally larger in size, the third case decreased in size. Interestingly, all patients had an excellent clinical response with normalization of HbA1c. Further study will be required to understand the natural history of pancreatic transplants from a pediatric donor. Volumetric assessment with magnetic resonance imaging (MRI) is proposed as the next step for better evaluation of graft size.