Paraneoplastic syndrome - a rare but treatable cause of non-thyroid-related extraocular muscle enlargement.
Orbit
; 38(6): 468-473, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-30523726
ABSTRACT
Paraneoplastic syndrome is a rare but reversible cause of non-thyroid-related extraocular muscle enlargement. We present a 71-year-old lady with diplopia, restricted eye movements, suppressed thyroid-stimulating hormone and enlargement of all extraocular muscles while on thyroxine replacement for hypothyroidism. She had distant history of metastatic breast cancer treated with chemotherapy, surgical resection and tamoxifen. She had negative anti-thyroid autoantibodies and thyroid ultrasound was not consistent with autoimmune thyroid disease. Carcinoembryonic antigen and cancer antigens 15-3, 125 and 72-4 were elevated, and whole-body positron emission tomography-computed tomography showed avid liver, left adrenal and skeletal lesions, with liver biopsy confirming breast cancer recurrence. She received prednisone and chemotherapy (letrozole, palbociclib) and achieved normalisation of eye movements and reduction in her EOME at 9-month follow-up. Our case highlights the importance of exploring paraneoplastic syndrome as a treatable cause of EOME in a patient lacking features of thyroid orbitopathy and autoimmune thyroid disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Síndromes Paraneoplásicas
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Neoplasias da Mama
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Carcinoma Ductal de Mama
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Músculos Oculomotores
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
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Female
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Humans
Idioma:
En
Revista:
Orbit
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália