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Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
Chiang, Annette N; Liang, Mary; Dominguez-Meijide, Antonio; Masaracchia, Caterina; Goeckeler-Fried, Jennifer L; Mazzone, Carly S; Newhouse, David W; Kendsersky, Nathan M; Yates, Megan E; Manos-Turvey, Alexandra; Needham, Patrick G; Outeiro, Tiago F; Wipf, Peter; Brodsky, Jeffrey L.
Afiliação
  • Chiang AN; Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA.
  • Liang M; Department of Chemistry, University of Pittsburgh, 758 Chevron Science Center, Pittsburgh, PA 15260, USA.
  • Dominguez-Meijide A; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.
  • Masaracchia C; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.
  • Goeckeler-Fried JL; Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA.
  • Mazzone CS; Department of Chemistry, University of Pittsburgh, 758 Chevron Science Center, Pittsburgh, PA 15260, USA.
  • Newhouse DW; Department of Chemistry, University of Pittsburgh, 758 Chevron Science Center, Pittsburgh, PA 15260, USA.
  • Kendsersky NM; Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA.
  • Yates ME; Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA.
  • Manos-Turvey A; Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA; Department of Chemistry, University of Pittsburgh, 758 Chevron Science Center, Pittsburgh, PA 15260, USA.
  • Needham PG; Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA.
  • Outeiro TF; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany; Max Planck Institute for Experimental Medicine, Göttingen, Germany; Ins
  • Wipf P; Department of Chemistry, University of Pittsburgh, 758 Chevron Science Center, Pittsburgh, PA 15260, USA.
  • Brodsky JL; Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA. Electronic address: jbrodsky@pitt.edu.
Bioorg Med Chem ; 27(1): 79-91, 2019 01 01.
Article em En | MEDLINE | ID: mdl-30528127
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Pirimidinonas / Adenosina Trifosfatases / Proteínas de Choque Térmico HSP70 / Ativadores de Enzimas / Ésteres / Multimerização Proteica Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Pirimidinonas / Adenosina Trifosfatases / Proteínas de Choque Térmico HSP70 / Ativadores de Enzimas / Ésteres / Multimerização Proteica Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos