Radiosynthesis, biological evaluation and preliminary microPET study of <sup>18</sup>F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90.

Kang, Julie; Young Lee, Jun; Tas, Isa; More, Kunal N; Kim, Hangun; Park, Jeong-Hoon; Chang, Dong-Jo

Radiosynthesis, biological evaluation and preliminary microPET study of ¹⁸F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90.

Kang, Julie; Young Lee, Jun; Tas, Isa; More, Kunal N; Kim, Hangun; Park, Jeong-Hoon; Chang, Dong-Jo.

Afiliação

Kang J; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922,Republic of Korea.
Young Lee J; Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea.
Tas I; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922,Republic of Korea.
More KN; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922,Republic of Korea.
Kim H; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922,Republic of Korea.
Park JH; Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea. Electronic address: parkjh@kaeri.re.kr.
Chang DJ; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922,Republic of Korea. Electronic address: djchang@sunchon.ac.kr.

Bioorg Med Chem Lett ; 28(23-24): 3658-3664, 2018 12 15.

Article em En | MEDLINE | ID: mdl-30528977

Assuntos

Proteínas de Choque Térmico HSP90/metabolismo; Compostos Radiofarmacêuticos/síntese química; Triazóis/química; Animais; Sítios de Ligação; Linhagem Celular Tumoral; Química Click; Cristalografia por Raios X; Estabilidade de Medicamentos; Radioisótopos de Flúor/química; Proteínas de Choque Térmico HSP90/química; Humanos; Camundongos; Camundongos Nus; Simulação de Acoplamento Molecular; Tomografia por Emissão de Pósitrons; Compostos Radiofarmacêuticos/sangue; Compostos Radiofarmacêuticos/metabolismo; Distribuição Tecidual; Transplante Heterólogo; Triazóis/sangue; Triazóis/metabolismo

Palavras-chave

Ganetespib; HSP 90; PET imaging; TNBC breast cancer; Tumor hypoxia

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Triazóis / Proteínas de Choque Térmico HSP90 / Compostos Radiofarmacêuticos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article

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