Biological monitoring of occupational ethylbenzene exposure by means of urinalysis for un-metabolized ethylbenzene.
Ind Health
; 57(4): 525-529, 2019 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-30531095
ABSTRACT
This study aimed to examine quantitative relation between ethylbenzene (EB) in air (EB-A) and un-metabolized EB in urine (EB-U) for biological monitoring of occupational EB exposure by urinalysis for EB. In total, 49 men in furniture production factories participated in the study. Time-weighted average EB-A was monitored by diffusive sampling. Urinalysis for EB was conducted by head-space gas-chromatography with end-of-shift samples. Data were subjected to regression analysis for statistical evaluation. A geometric mean (GM) and the maximum (Max) EB-A levels were 2.1 and 45.5â
ppm, respectively. A GM and the Max for EB-U (observed values) were 4.6 and 38.7â
µg/l. A significant linear correlation was observed. The regression equation was Y=3.1+0.73X where X is EB-A (ppm) and Y is EB-U (µg/l) (r=0.91, p<0.01). The significant correlation between EB-A and EB-U coupled with a small intercept suggests that biological monitoring of occupational EB exposure is possible by analysis for un-metabolized EB in end-of-shift urine samples. Further validation studies (including those on applicability to women) are envisaged. The feasibility should be examined for biological monitoring and the applicability of the equation among the workers exposed to EB at low levels.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Agentes_cancerigenos
Base de dados:
MEDLINE
Assunto principal:
Derivados de Benzeno
/
Exposição Ocupacional
Limite:
Adult
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Ind Health
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão