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Cytotoxic limonoids from the bark of Walsura cochinchinensis.
Trinh, Binh T D; Nguyen, Hiep D; Nguyen, Hieu T; Pham, Phuoc D; Ngo, Ngoc T N; Nguyen, Le-Thu T; Nguyen, Ly T T; Bui, Dzung N; Dang, Son V; Nguyen, Lien-Hoa D.
Afiliação
  • Trinh BTD; Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.
  • Nguyen HD; Faculty of Pharmacy, Ton Duc Thang University, 19 Nguyen Huu Tho, Ho Chi Minh City, Viet Nam.
  • Nguyen HT; Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.
  • Pham PD; Faculty of Pharmacy, Ton Duc Thang University, 19 Nguyen Huu Tho, Ho Chi Minh City, Viet Nam.
  • Ngo NTN; Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.
  • Nguyen LT; Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.
  • Nguyen LTT; Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.
  • Bui DN; Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.
  • Dang SV; Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam.
  • Nguyen LD; Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam. Electronic address: ndlhoa@hcmus.edu.vn.
Fitoterapia ; 133: 75-79, 2019 Mar.
Article em En | MEDLINE | ID: mdl-30576797
ABSTRACT
Three new limonoids, walsucochinones A-C (1-3), along with eight known compounds, were isolated from an ethyl acetate extract of the bark of Walsura cochinchinensis. Their structures were determined using spectroscopic techniques, mainly 1-D and 2-D NMR. The ethyl acetate extract showed cytotoxic activity against MCF-7 human breast cancer cells and cytotoxicity of the isolated compounds were evaluated in vitro using the SRB assay. Walsucochinone C (3) exhibited the most active effect with IC50 value of 16.4 ±â€¯0.2 µM.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Meliaceae / Casca de Planta / Limoninas / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Meliaceae / Casca de Planta / Limoninas / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2019 Tipo de documento: Article