Characterization of Soybean Germinated Embryo Extract as an Estrogen Receptor Subtype-Selective and Tissue-Specific Modulator.
J Med Food
; 22(2): 186-195, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30585749
ABSTRACT
Phytoestrogens possess beneficial effects in the management of menopausal symptoms with few side effects. Soybeans are major natural sources of isoflavones, with high estrogen receptor (ER)-ß selectivity. The objective of this study therefore was to develop a solvent-mediated extraction method for soybean germinated embryos (SGEs) and to investigate the biological activities of the extract. Ethanolic extraction yielded the SGE extract (SGEE), which had a unique composition of biologically active aglycones and soyasaponins. SGEE showed a proliferative effect in MCF7 cells and ERß-selective transcriptional activities in human embryonic kidney cells. In addition, oral administration of SGEE to ovariectomized rats resulted in the induction of ERß and estrogen-responsive genes in the uterus and a decrease in tail skin temperature and uterus weight. Our data suggest that germination and ethanolic extraction are effective measures for producing isoflavone-rich food supplements, which may be useful as alternative menopausal hormone therapy.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Saude_da_mulher
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Colo_do_utero
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Colo_do_utero
Base de dados:
MEDLINE
Assunto principal:
Saponinas
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Pele
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Glycine max
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Útero
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Extratos Vegetais
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Moduladores Seletivos de Receptor Estrogênico
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Receptor beta de Estrogênio
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
J Med Food
Assunto da revista:
CIENCIAS DA NUTRICAO
/
MEDICINA
Ano de publicação:
2019
Tipo de documento:
Article