Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial.

Athauda, Dilan; Gulyani, Seema; Karnati, Hanuma Kumar; Li, Yazhou; Tweedie, David; Mustapic, Maja; Chawla, Sahil; Chowdhury, Kashfia; Skene, Simon S; Greig, Nigel H; Kapogiannis, Dimitrios; Foltynie, Thomas

Athauda, Dilan; Gulyani, Seema; Karnati, Hanuma Kumar; Li, Yazhou; Tweedie, David; Mustapic, Maja; Chawla, Sahil; Chowdhury, Kashfia; Skene, Simon S; Greig, Nigel H; Kapogiannis, Dimitrios; Foltynie, Thomas.

Afiliação

Athauda D; Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Gulyani S; Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Karnati HK; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Li Y; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Tweedie D; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Mustapic M; Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Chawla S; Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Chowdhury K; University College London Comprehensive Clinical Trials Unit, London, United Kingdom.
Skene SS; University College London Comprehensive Clinical Trials Unit, London, United Kingdom.
Greig NH; School of Biosciences and Medicine, University of Surrey, Kent, United Kingdom.
Kapogiannis D; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Foltynie T; Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

JAMA Neurol ; 76(4): 420-429, 2019 04 01.

Article em En | MEDLINE | ID: mdl-30640362

Assuntos

Exossomos/metabolismo; Insulina/metabolismo; Neurônios/metabolismo; Doença de Parkinson/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Adulto; Idoso; Encéfalo/metabolismo; Exenatida/uso terapêutico; Feminino; Humanos; Incretinas/uso terapêutico; Proteínas Substratos do Receptor de Insulina/metabolismo; Janus Quinases/metabolismo; Sistema de Sinalização das MAP Quinases; Masculino; Pessoa de Meia-Idade; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; Doença de Parkinson/tratamento farmacológico; Fosforilação; Transdução de Sinais

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Proto-Oncogênicas c-akt / Exossomos / Serina-Treonina Quinases TOR / Insulina / Neurônios Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: JAMA Neurol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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