Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.

Chen, Chiung-Mei; Chen, Wan-Ling; Hung, Chen-Ting; Lin, Te-Hsien; Lee, Ming-Chung; Chen, I-Cheng; Lin, Chih-Hsin; Chao, Chih-Ying; Wu, Yih-Ru; Chang, Kuo-Hsuan; Hsieh-Li, Hsiu Mei; Lee-Chen, Guey-Jen

Chen, Chiung-Mei; Chen, Wan-Ling; Hung, Chen-Ting; Lin, Te-Hsien; Lee, Ming-Chung; Chen, I-Cheng; Lin, Chih-Hsin; Chao, Chih-Ying; Wu, Yih-Ru; Chang, Kuo-Hsuan; Hsieh-Li, Hsiu Mei; Lee-Chen, Guey-Jen.

Afiliação

Chen CM; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
Chen WL; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
Hung CT; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Lin TH; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Lee MC; Brion Research Institute, New Taipei City 23143, Taiwan.
Chen IC; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
Lin CH; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
Chao CY; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
Wu YR; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
Chang KH; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
Hsieh-Li HM; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Lee-Chen GJ; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.

Aging (Albany NY) ; 11(3): 986-1007, 2019 02 13.

Article em En | MEDLINE | ID: mdl-30760647

Assuntos

Medicamentos de Ervas Chinesas/farmacologia; Medicamentos de Ervas Chinesas/uso terapêutico; Ataxias Espinocerebelares/tratamento farmacológico; Animais; Fator de Ligação a CCAAT/genética; Fator de Ligação a CCAAT/metabolismo; Linhagem Celular; Avaliação Pré-Clínica de Medicamentos; Técnicas de Silenciamento de Genes; Glycyrrhiza uralensis; Humanos; Camundongos Transgênicos; Terapia de Alvo Molecular; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Crescimento Neuronal/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Paeonia; Peptídeos/metabolismo; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Fitoterapia; Ataxias Espinocerebelares/metabolismo; Proteína de Ligação a TATA-Box/efeitos dos fármacos; Proteína de Ligação a TATA-Box/metabolismo

Palavras-chave

NFYA; NRF2; PGC-1α; Shaoyao Gancao Tang; oxidative stress; polyQ aggregates; spinocerebellar ataxia 17/TBP

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Ataxias Espinocerebelares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Taiwan

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