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The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases.
Ippen, Franziska M; Alvarez-Breckenridge, Christopher A; Kuter, Benjamin M; Fink, Alexandria L; Bihun, Ivanna V; Lastrapes, Matthew; Penson, Tristan; Schmidt, Stephen P; Wojtkiewicz, Gregory R; Ning, Jianfang; Subramanian, Megha; Giobbie-Hurder, Anita; Martinez-Lage, Maria; Carter, Scott L; Cahill, Daniel P; Wakimoto, Hiroaki; Brastianos, Priscilla K.
Afiliação
  • Ippen FM; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Alvarez-Breckenridge CA; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Kuter BM; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Fink AL; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Bihun IV; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Lastrapes M; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Penson T; Joint Center for Cancer Precision Medicine, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Schmidt SP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Wojtkiewicz GR; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Ning J; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Subramanian M; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Giobbie-Hurder A; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Martinez-Lage M; Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Carter SL; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Cahill DP; Joint Center for Cancer Precision Medicine, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Brastianos PK; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Clin Cancer Res ; 25(11): 3374-3383, 2019 06 01.
Article em En | MEDLINE | ID: mdl-30796030
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Oxazinas / Pirimidinas / Neoplasias Encefálicas / Neoplasias da Mama / Transdução de Sinais / Classe I de Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR Limite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Oxazinas / Pirimidinas / Neoplasias Encefálicas / Neoplasias da Mama / Transdução de Sinais / Classe I de Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR Limite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article