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A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity.
Wang, Shuai; Chen, Buyun; Dragovich, Peter; Pillow, Thomas; Staben, Leanna; Guo, Jun; Su, Dian; Zhang, Chenghong; Bobba, Sudheer; Ma, Yong; Wang, Jianshuang; Sangaraju, Dewakar; Wei, BinQing; Phillips, Gail Lewis; Khojasteh, Cyrus; Zhang, Donglu.
Afiliação
  • Wang S; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California wangshuai66@gmail.com.
  • Chen B; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Dragovich P; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Pillow T; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Staben L; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Guo J; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Su D; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Zhang C; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Bobba S; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Ma Y; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Wang J; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Sangaraju D; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Wei B; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Phillips GL; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Khojasteh C; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California.
  • Zhang D; Drug Metabolism and Pharmacokinetics (S.W., B.C., D.Su., C.Z., S.B., Y.M., J.W., D.Sa., C.K., D.Z.), Discovery Chemistry (P.D., T.P., L.S., B.W.), and Discovery Biology (J.G., G.L.P.), Genentech, Inc., South San Francisco, California zhang.donglu@gene.com.
Drug Metab Dispos ; 47(5): 547-555, 2019 05.
Article em En | MEDLINE | ID: mdl-30858239
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: DNA / Antineoplásicos Alquilantes / Alquilação / Duocarmicinas Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: DNA / Antineoplásicos Alquilantes / Alquilação / Duocarmicinas Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article