Sacculatane diterpenoids from the Chinese liverwort Pellia epiphylla with protection against H<sub>2</sub>O<sub>2</sub>-induced apoptosis of PC12â¯cells.

Li, Yi; Sun, Yong; Zhu, Mingzhu; Zhu, Rongxiu; Zhang, Jiaozhen; Zhou, Jinchuan; Wang, Tian; Qiao, Yanan; Lou, Hongxiang

Sacculatane diterpenoids from the Chinese liverwort Pellia epiphylla with protection against H₂O₂-induced apoptosis of PC12â¯cells.

Li, Yi; Sun, Yong; Zhu, Mingzhu; Zhu, Rongxiu; Zhang, Jiaozhen; Zhou, Jinchuan; Wang, Tian; Qiao, Yanan; Lou, Hongxiang.

Afiliação

Li Y; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China.
Sun Y; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China.
Zhu M; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China.
Zhu R; School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250010, People's Republic of China.
Zhang J; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China.
Zhou J; School of Pharmacy, Linyi University, Linyi, 276000, People's Republic of China.
Wang T; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China.
Qiao Y; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China.
Lou H; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China. Electronic address: louhongxiang@sdu.edu.cn.

Phytochemistry ; 162: 173-182, 2019 Jun.

Article em En | MEDLINE | ID: mdl-30925378

ABSTRACT

ABSTRACT

Eight previously undescribed sacculatane diterpenoids, epiphyllins A-H, and one unknown bibenzyl-based isopentene along with seven known compounds were isolated from the Chinese liverwort Pellia epiphylla (L.) Corda. Their structures were established unequivocally on the basis of spectroscopic data and CD measurement. The quinine reductase-inducing activity evaluation demonstrated that epiphyllins A-D, 1ß-hydroxysacculatanolide and pellianolactone B displayed moderate antioxidant effect. Further investigation of pellianolactone B revealed its protective effects on H2O2-induced oxidative insults and apoptosis in PC12â¯cells.

Assuntos

Apoptose/efeitos dos fármacos; Citoproteção/efeitos dos fármacos; Diterpenos/química; Diterpenos/farmacologia; Hepatófitas/química; Peróxido de Hidrogênio/farmacologia; Sáculo e Utrículo/química; Animais; Antioxidantes/química; Antioxidantes/farmacologia; Modelos Moleculares; Conformação Molecular; Células PC12; Ratos

Palavras-chave

Apoptosis; Epiphyllins A−H; Liverworts; PC12â¯cells; Pellia epiphylla (L.) Corda; Pelliaceae; Sacculatane diterpenoids

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Sáculo e Utrículo / Apoptose / Citoproteção / Hepatófitas / Diterpenos / Peróxido de Hidrogênio Limite: Animals Idioma: En Revista: Phytochemistry Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google