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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma.
López, Cristina; Kleinheinz, Kortine; Aukema, Sietse M; Rohde, Marius; Bernhart, Stephan H; Hübschmann, Daniel; Wagener, Rabea; Toprak, Umut H; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F; Szczepanowski, Monika; Weniger, Marc A; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Möller, Peter; Trümper, Lorenz.
Afiliação
  • López C; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.
  • Kleinheinz K; Institute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
  • Aukema SM; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Rohde M; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, 69120, Heidelberg, Germany.
  • Bernhart SH; Institute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
  • Hübschmann D; Hematopathology Section, Christian-Albrechts-University, 24105, Kiel, Germany.
  • Wagener R; Pediatric Hematology and Oncology, University Hospital Giessen, 35392, Giessen, Germany.
  • Toprak UH; Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
  • Raimondi F; Bioinformatics Group, Department of Computer, University of Leipzig, 04107, Leipzig, Germany.
  • Kreuz M; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, 04107, Leipzig, Germany.
  • Waszak SM; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Huang Z; Department of Pediatric Immunology, Hematology and Oncology, University Hospital, 69120, Heidelberg, Germany.
  • Sieverling L; German Cancer Research Center (DKFZ), Division of Stem Cells and Cancer, Heidelberg, Germany and Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.
  • Paramasivam N; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.
  • Seufert J; Institute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
  • Sungalee S; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Russell RB; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Bausinger J; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.
  • Kretzmer H; Cell Networks, Bioquant and Biochemistry CenterBiochemie Zentrum Heidelberg (BZH), University of Heidelberg, 69120, Heidelberg, Germany.
  • Ammerpohl O; Institute for Medical Informatics Statistics and Epidemiology, 04107, Leipzig, Germany.
  • Bergmann AK; Genome Biology Unit, EMBL Heidelberg, 69117, Heidelberg, Germany.
  • Binder H; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Borkhardt A; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.
  • Brors B; Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Claviez A; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Doose G; Medical Faculty Heidelberg, Heidelberg University, 69120, Heidelber, Germany.
  • Feuerbach L; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Haake A; Genome Biology Unit, EMBL Heidelberg, 69117, Heidelberg, Germany.
  • Hansmann ML; Cell Networks, Bioquant and Biochemistry CenterBiochemie Zentrum Heidelberg (BZH), University of Heidelberg, 69120, Heidelberg, Germany.
  • Hoell J; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.
  • Hummel M; Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
  • Korbel JO; Bioinformatics Group, Department of Computer, University of Leipzig, 04107, Leipzig, Germany.
  • Lawerenz C; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, 04107, Leipzig, Germany.
  • Lenze D; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany.
  • Radlwimmer B; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany.
  • Richter J; Institute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
  • Rosenstiel P; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany.
  • Rosenwald A; Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
  • Schilhabel MB; Bioinformatics Group, Department of Computer, University of Leipzig, 04107, Leipzig, Germany.
  • Stein H; Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
  • Stilgenbauer S; Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Stadler PF; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany.
  • Szczepanowski M; Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany.
  • Weniger MA; Bioinformatics Group, Department of Computer, University of Leipzig, 04107, Leipzig, Germany.
  • Zapatka M; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, 04107, Leipzig, Germany.
  • Eils R; Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Lichter P; Institute of Human Genetics, Christian-Albrechts-University, 24105, Kiel, Germany.
  • Loeffler M; Senckenberg Institute of Pathology, University of Frankfurt Medical School, 60590, Frankfurt am Main, Germany.
  • Möller P; Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
  • Trümper L; Institute of Pathology, Charité - University Medicine Berlin, 10117, Berlin, Germany.
Nat Commun ; 10(1): 1459, 2019 03 29.
Article em En | MEDLINE | ID: mdl-30926794
ABSTRACT
Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Genoma Humano / Linfoma de Burkitt / Transcriptoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Genoma Humano / Linfoma de Burkitt / Transcriptoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha