Development and testing of the KnowGene scale to assess general cancer genetic knowledge related to multigene panel testing.
Patient Educ Couns
; 102(8): 1558-1564, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31010603
ABSTRACT
PURPOSE:
To develop and evaluate a measure of cancer genetics knowledge relevant to multigene panel testing.METHODS:
The instrument was developed using systematic input from a national panel of genetics experts, acceptability evaluation by patient advocates, and cognitive testing. Twenty-four candidate items were completed by 591 breast or gynecological patients who had undergone genetic counseling and multigene panel testing in the past 18 months. A unidimensional item response theory model was fit with a mix of 2-parameter logistic nested response (2 plnrm) and 2-parameter logistic (2 pl) items.RESULTS:
Key domains addressing cancer genetics knowledge were found to be overlapping. Of the 24 candidate items, 8 items were removed due to poor discrimination or local dependence. The remaining 16 items had good fit (RMSEA = 0.045, CFI = 0.946) and discrimination parameters ranging from 0.49 to 1.60. The items specified as 2 plnrm distinguish between those answering incorrect versus don't know, with discrimination ranging from 0.51 to 1.02. Information curves were highest among those with lower knowledge.CONCLUSION:
KnowGene is a rigorously developed and effective measure of knowledge after cancer genetic counseling and multigene panel testing. PRACTICE IMPLICATIONS Measuring knowledge in a systematic way will inform practice and research initiatives in cancer genetics.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Prevencao_e_fatores_de_risco
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Hereditariedade
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Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Testes Genéticos
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Conhecimentos, Atitudes e Prática em Saúde
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Aconselhamento Genético
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Neoplasias dos Genitais Femininos
Tipo de estudo:
Prognostic_studies
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Qualitative_research
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Patient Educ Couns
Ano de publicação:
2019
Tipo de documento:
Article