Correlation between the solid state of lipid coating and release profile of API from hot melt coated microcapsules.

Salar-Behzadi, Sharareh; Corzo, Carolina; Schaden, Lisa; Laggner, Peter; Zimmer, Andreas

Salar-Behzadi, Sharareh; Corzo, Carolina; Schaden, Lisa; Laggner, Peter; Zimmer, Andreas.

Afiliação

Salar-Behzadi S; Research Center for Pharmaceutical Engineering GmbH, Graz, Austria; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, Austria. Electronic address: sharareh.salar@rcpe.at.
Corzo C; Research Center for Pharmaceutical Engineering GmbH, Graz, Austria; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, Austria.
Schaden L; Research Center for Pharmaceutical Engineering GmbH, Graz, Austria.
Laggner P; Research Center for Pharmaceutical Engineering GmbH, Graz, Austria.
Zimmer A; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, Austria.

Int J Pharm ; 565: 569-578, 2019 Jun 30.

Article em En | MEDLINE | ID: mdl-31100383

Assuntos

Cápsulas/química; Tecnologia Farmacêutica/métodos; Acetilcisteína/química; Cristalização; Liberação Controlada de Fármacos; Estabilidade de Medicamentos; Excipientes/química; Ácidos Graxos/química; Glicerídeos/química

Palavras-chave

Hot melt coating; Instability; Lipid-based excipients; Microstructure; Release profile; Solid state alteration

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Cápsulas / Tecnologia Farmacêutica Idioma: En Revista: Int J Pharm Ano de publicação: 2019 Tipo de documento: Article

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