Constant expression of somatostatin receptor 2a in minute pulmonary meningothelial-like nodules.
J Clin Pathol
; 72(8): 525-528, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-31208995
ABSTRACT
AIMS:
Although ultrastructural studies showed that minute pulmonary meningothelial-like nodules (MPMNs) cells closely resembled meningothelial cells, their immunophenotype has not been well characterised, partly due to their rarity.METHODS:
Somatostatin receptor 2a (SSTR2a) and other markers of meningioma, including epithelial membrane antigen (EMA), progesterone receptor (PR) and S100, were analysed retrospectively in 19 MPMN cases from two institutions in China.RESULTS:
The median age of patients with MPMNs was 62.5 years (32-73 years), with a male-to-female ratio of 18.5. Most (15/19) patients with MPMNs had coexisting diseases, including adenocarcinomas (12 cases), bronchiectasis (1 case) and tuberculosis (2 cases). Just over half of the cases (10/19) were multifocal lesions (2-5 lesions). An additional 53 cases with 123 lesions from the literature were reviewed with reported immunophenotype information. In total, 162 lesions were included in the analysis. The size of nodules was 1-4 mm. All MPMN lesions (39/39) in the 19 cases showed strong and diffuse cytoplasmic expression of SSTR2a. The expression rate of SSTR2a was higher than that of conventional markers of meningioma, including EMA (86/138), PR (32/68) and S100 (1/125).CONCLUSIONS:
Our observations expand the spectrum of recognised SSTR2a-positive lesions and once again demonstrated that MPMNs show immunohistochemical characteristics similar to meningothelial cells.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Pulmao
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Receptores de Somatostatina
/
Nódulos Pulmonares Múltiplos
/
Neoplasias Pulmonares
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Neoplasias Meníngeas
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Meningioma
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Clin Pathol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China