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Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia.
Xie, Chun-Lan; Chen, Renzhi; Yang, Sihan; Xia, Jin-Mei; Zhang, Gai-Yun; Chen, Chao-Hong; Zhang, Yandong; Yang, Xian-Wen.
Afiliação
  • Xie CL; Key Laboratory of Marine Biogenetic Resources , Third Institute of Oceanography, Ministry of Natural Resources , 184 Daxue Road , Xiamen , Fujian 361005 , China.
  • Chen R; School of Pharmaceutical Sciences , Xiamen University , South Xiangan Road , Xiamen , Fujian 361102 , China.
  • Yang S; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , Fujian 361005 , China.
  • Xia JM; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , Fujian 361005 , China.
  • Zhang GY; Key Laboratory of Marine Biogenetic Resources , Third Institute of Oceanography, Ministry of Natural Resources , 184 Daxue Road , Xiamen , Fujian 361005 , China.
  • Chen CH; Key Laboratory of Marine Biogenetic Resources , Third Institute of Oceanography, Ministry of Natural Resources , 184 Daxue Road , Xiamen , Fujian 361005 , China.
  • Zhang Y; Key Laboratory of Marine Biogenetic Resources , Third Institute of Oceanography, Ministry of Natural Resources , 184 Daxue Road , Xiamen , Fujian 361005 , China.
  • Yang XW; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , Fujian 361005 , China.
Org Lett ; 21(20): 8174-8177, 2019 10 18.
Article em En | MEDLINE | ID: mdl-31423796
ABSTRACT
An intriguing cage-like polyhemiketal, nesteretal A (1), was isolated from the coral-derived actinomycete Nesterenkonia halobia. Its structure was established by extensive spectroscopic and computational methods. Nesteretal A is a highly oxygenated compound featuring an unprecedented 5/5/5/5 tetracyclic scaffold. A possible biosynthetic pathway of 1 from naturally occurring diacetyl was proposed. Compound 1 showed a weak retinoid X receptor-α (RXRα) transcriptional activation effect.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Actinobacteria / Receptor X Retinoide alfa / Policetídeos Limite: Humans Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Actinobacteria / Receptor X Retinoide alfa / Policetídeos Limite: Humans Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China