Enzymatic formation of glidobactamine: a peptide nucleus of glidobactins A, B and C, new lipopeptide antitumor antibiotics.
J Antibiot (Tokyo)
; 41(10): 1351-7, 1988 Oct.
Article
em En
| MEDLINE
| ID: mdl-3142842
ABSTRACT
Glidobactin deacylating activity was found in a bacterial strain of Pseudomonas sp. Glidobactamine, a key intermediate for acyl analogues of glidobactin, was isolated from the enzymatic degradation products of glidobactins after treatment using a column of fibrous active gel on which the cells of the Pseudomonas strain were immobilized. The chemical structure of glidobactamine was confirmed as the intact peptide moiety of glidobactins by chemical reformation of glidobactin A from glidobactamine and 2,4-dodecadienoic acid which is the constitutive fatty acid of glidobactin A.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Treonina
/
Antibióticos Antineoplásicos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Japão