Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls.
Front Cell Infect Microbiol
; 9: 294, 2019.
Article
em En
| MEDLINE
| ID: mdl-31555603
ABSTRACT
Condyloma acuminatum (CA) is a benign epithelium hyperplasia mainly caused by human papillomavirus (HPV), which is now the second most common viral sexually transmitted infection (STI) in China. In total, 90% of CA patients are caused by the low-risk HPV 6 and 11. Aside from low-risk HPV infection there are likely other factors within the local microenvironment that contribute to CA and there has been related research before. In this study, 62 vaginal specimens were analyzed using 16S rRNA gene sequencing. The diversity of the vaginal microbiota was higher and the composition was different with LR-HPV infection. While the relative abundance of dominant Firmicutes was lower, Actinobacteria, Proteobacteria, and Fusobacteria phyla were significantly higher; at the genus level Gardnerella, Bifidobacterium, Sneathia, Hydrogenophilus, Burkholderia, and Atopobium were higher. This study firstly confirmed a more accurate and comprehensive understanding of the relationship between low-risk HPV infection and vaginal microbiota, in order to provide a theoretical basis for further research on the occurrence and development of CA.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Vagina
/
Infecções por Papillomavirus
/
Microbiota
Limite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
Front Cell Infect Microbiol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China