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Small-Molecule Antiviral ß-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.
Agostini, Maria L; Pruijssers, Andrea J; Chappell, James D; Gribble, Jennifer; Lu, Xiaotao; Andres, Erica L; Bluemling, Gregory R; Lockwood, Mark A; Sheahan, Timothy P; Sims, Amy C; Natchus, Michael G; Saindane, Manohar; Kolykhalov, Alexander A; Painter, George R; Baric, Ralph S; Denison, Mark R.
Afiliação
  • Agostini ML; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Pruijssers AJ; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Chappell JD; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Gribble J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Lu X; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Andres EL; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Bluemling GR; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
  • Lockwood MA; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
  • Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Sims AC; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Natchus MG; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
  • Saindane M; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
  • Kolykhalov AA; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
  • Painter GR; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
  • Baric RS; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Denison MR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Virol ; 93(24)2019 12 15.
Article em En | MEDLINE | ID: mdl-31578288
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite Murina / Citidina / Coronavírus da Síndrome Respiratória do Oriente Médio Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite Murina / Citidina / Coronavírus da Síndrome Respiratória do Oriente Médio Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos