Cobalt Oxyhydroxide-prompted Synthesis of Fluorescent Polydopamine Nanoparticles for Glutathione Detection.
Anal Sci
; 36(3): 347-352, 2020 Mar 10.
Article
em En
| MEDLINE
| ID: mdl-31656249
ABSTRACT
Glutathione (GSH) plays an important role in cells, which is an essential endogenous antioxidant. Here, we have developed a new detection platform to analyze GSH levels. In our system, fluorescent polydopamine (PDA) nanoparticles, as signal indicators, were obtained by oxidation through cobalt oxyhydroxide (CoOOH) nanosheets. When CoOOH was present, CoOOH could quickly oxidize dopamine to fluorescent PDA nanoparticles. However, once GSH existed, CoOOH nanosheets were decomposed into Co2+, and oxidation between CoOOH and dopamine was prevented with weaker fluorescence occurring. Thus, we could realize detection of the GSH concentration according to the decreased fluorescence value of the fluorescent polydopamine. This method provides a fast, simple, high sensitivity and desirable selectivity platform for GSH monitoring.
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Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Nanopartículas
/
Glutationa
/
Indóis
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Anal Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China