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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Schmidt, Amand F; Holmes, Michael V; Preiss, David; Swerdlow, Daniel I; Denaxas, Spiros; Fatemifar, Ghazaleh; Faraway, Rupert; Finan, Chris; Valentine, Dennis; Fairhurst-Hunter, Zammy; Hartwig, Fernando Pires; Horta, Bernardo Lessa; Hypponen, Elina; Power, Christine; Moldovan, Max; van Iperen, Erik; Hovingh, Kees; Demuth, Ilja; Norman, Kristina; Steinhagen-Thiessen, Elisabeth; Demuth, Juri; Bertram, Lars; Lill, Christina M; Coassin, Stefan; Willeit, Johann; Kiechl, Stefan; Willeit, Karin; Mason, Dan; Wright, John; Morris, Richard; Wanamethee, Goya; Whincup, Peter; Ben-Shlomo, Yoav; McLachlan, Stela; Price, Jackie F; Kivimaki, Mika; Welch, Catherine; Sanchez-Galvez, Adelaida; Marques-Vidal, Pedro; Nicolaides, Andrew; Panayiotou, Andrie G; Onland-Moret, N Charlotte; van der Schouw, Yvonne T; Matullo, Giuseppe; Fiorito, Giovanni; Guarrera, Simonetta; Sacerdote, Carlotta; Wareham, Nicholas J; Langenberg, Claudia; Scott, Robert A.
Afiliação
  • Schmidt AF; Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK. amand.schmidt@ucl.ac.uk.
  • Holmes MV; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. amand.schmidt@ucl.ac.uk.
  • Preiss D; UCL's BHF Research Accelerator Centre, London, UK. amand.schmidt@ucl.ac.uk.
  • Swerdlow DI; Medical Research Council Population Health Research Unit, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Denaxas S; Medical Research Council Population Health Research Unit, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Fatemifar G; Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
  • Faraway R; Department of Medicine, Imperial College London, London, UK.
  • Finan C; UCL's BHF Research Accelerator Centre, London, UK.
  • Valentine D; Health Data Research UK, University College London, 222 Euston Road, London, NW1 2DA, UK.
  • Fairhurst-Hunter Z; Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, UK.
  • Hartwig FP; The Alan Turing Institute, British Library, 96 Euston Rd, London, NW1 2DB, UK.
  • Horta BL; UCL's BHF Research Accelerator Centre, London, UK.
  • Hypponen E; Health Data Research UK, University College London, 222 Euston Road, London, NW1 2DA, UK.
  • Power C; Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, UK.
  • Moldovan M; Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
  • van Iperen E; Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
  • Hovingh K; UCL's BHF Research Accelerator Centre, London, UK.
  • Demuth I; UCL's BHF Research Accelerator Centre, London, UK.
  • Norman K; University College London, Farr Institute of Health Informatics, London, UK.
  • Steinhagen-Thiessen E; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK.
  • Demuth J; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
  • Bertram L; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
  • Lill CM; Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
  • Coassin S; Population, Policy and Practice, UCL GOS Institute of Child Health, London, UK.
  • Willeit J; South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Kiechl S; Population, Policy and Practice, UCL GOS Institute of Child Health, London, UK.
  • Willeit K; South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Mason D; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands.
  • Wright J; Department of Clinical Epidemiology, Biostatistics And Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
  • Morris R; Department of vascular medicine, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
  • Wanamethee G; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.
  • Whincup P; Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany.
  • Ben-Shlomo Y; Institute of Nutritional Science, University of Potsdam, 14558, Nuthetal, Germany.
  • McLachlan S; Geriatrics Research Group, Charité - Universitätsmedizin Berlin, 13347, Berlin, Germany.
  • Price JF; Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558, Nuthetal, Germany.
  • Kivimaki M; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.
  • Welch C; E.CA Economics GmbH, Berlin, Germany.
  • Sanchez-Galvez A; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
  • Marques-Vidal P; Center for Lifespan Changes in Brain and Cognition (LCBC), Dept. Psychology, University of Oslo, Oslo, Norway.
  • Nicolaides A; Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
  • Panayiotou AG; Institute of Human Genetics, Lübeck, Germany.
  • Onland-Moret NC; Ageing Epidemiology Research Unit, School of Public Health, Imperial College, London, UK.
  • van der Schouw YT; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, 6020, Innsbruck, Austria.
  • Matullo G; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
  • Fiorito G; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
  • Guarrera S; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
  • Sacerdote C; Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
  • Wareham NJ; Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
  • Langenberg C; Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
  • Scott RA; Department Primary Care & Population Health, University College London, London, UK.
BMC Cardiovasc Disord ; 19(1): 240, 2019 10 29.
Article em En | MEDLINE | ID: mdl-31664920
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Inibidores de Serina Proteinase / Polimorfismo de Nucleotídeo Único / Dislipidemias / Pró-Proteína Convertase 9 / Inibidores de PCSK9 / LDL-Colesterol / Anticolesterolemiantes Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Cardiovasc Disord Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Inibidores de Serina Proteinase / Polimorfismo de Nucleotídeo Único / Dislipidemias / Pró-Proteína Convertase 9 / Inibidores de PCSK9 / LDL-Colesterol / Anticolesterolemiantes Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Cardiovasc Disord Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido