Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells.

Abdul, Naeem Sheik; Nagiah, Savania; Anand, Krisnan; Chuturgoon, Anil A

Abdul, Naeem Sheik; Nagiah, Savania; Anand, Krisnan; Chuturgoon, Anil A.

Afiliação

Abdul NS; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Nagiah S; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Anand K; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Chuturgoon AA; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa. Electronic address: chutur@ukzn.ac.za.

Toxicon ; 173: 48-56, 2020 Jan 15.

Article em En | MEDLINE | ID: mdl-31778683

Assuntos

Ácido Fusárico/toxicidade; Mitocôndrias/efeitos dos fármacos; Micotoxinas/toxicidade; Sirtuínas/efeitos dos fármacos; Animais; Carcinoma Hepatocelular; Células Hep G2; Humanos; Neoplasias Hepáticas; Simulação de Acoplamento Molecular; Estresse Oxidativo; Sirtuínas/fisiologia

Palavras-chave

Fusaric acid; Micro RNA; Molecular docking; PGC-1α; Post translational modifications; Sirtuins

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Ácido Fusárico / Sirtuínas / Mitocôndrias / Micotoxinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Toxicon Ano de publicação: 2020 Tipo de documento: Article País de afiliação: África do Sul

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