Identification of the minimal N-glycosylation on integrin &#945;5ß1 required for its inhibitory effect on EGFR signaling and cell proliferation.

Hou, Sicong; Hang, Qinglei; Isaji, Tomoya; Fukuda, Tomohiko; Gu, Jianguo

Identification of the minimal N-glycosylation on integrin α5ß1 required for its inhibitory effect on EGFR signaling and cell proliferation.

Hou, Sicong; Hang, Qinglei; Isaji, Tomoya; Fukuda, Tomohiko; Gu, Jianguo.

Afiliação

Hou S; Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, China; Department of Clinical Medicine, Medical College, Yangzhou University, Yangzhou, 225001, China; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycob
Hang Q; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aobaku, Sendai, Miyagi, 981-8558, Japan.
Isaji T; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aobaku, Sendai, Miyagi, 981-8558, Japan.
Fukuda T; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aobaku, Sendai, Miyagi, 981-8558, Japan.
Gu J; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aobaku, Sendai, Miyagi, 981-8558, Japan. Electronic address: jgu@tohoku-mpu.ac.jp.

Biochem Biophys Res Commun ; 523(1): 226-232, 2020 02 26.

Article em En | MEDLINE | ID: mdl-31858971

Assuntos

Integrina alfa5beta1/metabolismo; Polissacarídeos/farmacologia; Transdução de Sinais/efeitos dos fármacos; Adesão Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/metabolismo; Glicosilação; Humanos; Integrina alfa5beta1/genética; Mutação

Palavras-chave

Cell proliferation; Cell signaling; EGFR; Integrin; N-Glycosylation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Polissacarídeos / Transdução de Sinais / Integrina alfa5beta1 Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google