Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens.
Org Lett
; 22(1): 257-260, 2020 01 03.
Article
em En
| MEDLINE
| ID: mdl-31860319
ABSTRACT
Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro. Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Aporfinas
/
Extratos Vegetais
/
Anti-Inflamatórios não Esteroides
/
Papaveraceae
/
Analgésicos
Limite:
Animals
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China