Novel linked butanolide dimer compounds increase adiponectin production during adipogenesis in human mesenchymal stem cells through peroxisome proliferator-activated receptor Î³ modulation.

Ahn, Sungjin; Basavana Gowda, M K; Lee, Moonyoung; Masagalli, Jagadeesh Nagarajappa; Mailar, Karabasappa; Choi, Won Jun; Noh, Minsoo

Ahn, Sungjin; Basavana Gowda, M K; Lee, Moonyoung; Masagalli, Jagadeesh Nagarajappa; Mailar, Karabasappa; Choi, Won Jun; Noh, Minsoo.

Afiliação

Ahn S; Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Basavana Gowda MK; College of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Goyang, Gyeonggi-do, 10326, Republic of Korea.
Lee M; Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Masagalli JN; College of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Goyang, Gyeonggi-do, 10326, Republic of Korea.
Mailar K; College of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Goyang, Gyeonggi-do, 10326, Republic of Korea.
Choi WJ; College of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Goyang, Gyeonggi-do, 10326, Republic of Korea. Electronic address: mp89@dongguk.edu.
Noh M; Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. Electronic address: minsoonoh@snu.ac.kr.

Eur J Med Chem ; 187: 111969, 2020 Feb 01.

Article em En | MEDLINE | ID: mdl-31865018

Assuntos

4-Butirolactona/farmacologia; Adipogenia/efeitos dos fármacos; Adiponectina/biossíntese; Células-Tronco Mesenquimais/efeitos dos fármacos; PPAR gama/agonistas; 4-Butirolactona/análogos & derivados; 4-Butirolactona/química; Células Cultivadas; Dimerização; Relação Dose-Resposta a Droga; Humanos; Células-Tronco Mesenquimais/metabolismo; Modelos Moleculares; Simulação de Acoplamento Molecular; Estrutura Molecular; PPAR gama/metabolismo; Relação Estrutura-Atividade

Palavras-chave

Adiponectin; Human bone marrow mesenchymal stem cells; Linked butanolide dimers; PPARÎ³

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: 4-Butirolactona / PPAR gama / Adiponectina / Adipogenia / Células-Tronco Mesenquimais Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article

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